mouse MEF2C shRNA silencing AAV

Name
AAV-m-MEF2C-shRNA

Cat No
shAAV-264473

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Mouse Mef2c.

shAAV-264473

AAV-m-MEF2C-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Mef2c (myocyte enhancer factor 2C). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

5430401D19Rik; 9930028G15Rik; AV011172; Mef2

Description (Vector)

Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.

Gene ID

17260

Gene Name (Vector)

myocyte enhancer factor 2C

Gene Symbol

Mef2c

ORF Size (aa)

1329

ORF Size (bp)

1329 bp

RefSeq ID

NM_025282

RefSeq Synonyms

NM_025282, NM_001347581, NM_001347580, NM_001347579, NM_001347578, NM_001347577, NM_001347576, NM_001347575, NM_001347574, NM_001347573, NM_001347572, NM_001347571, NM_001347569, NM_001347568, NM_001347567, NM_001347566, NM_001347564, NM_001170537, BC057650, BC037731, BC026841,

Species

mouse

UniGene ID

Mm.451574

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.