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mouse MBNL3 shRNA silencing AAV

Name 
AAV-m-MBNL3-shRNA
Cat No 
shAAV-264326
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse Mbnl3.

shAAV-264326
AAV-m-MBNL3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Mbnl3 (muscleblind-like 3 (Drosophila)). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
A530038J18Rik; AI661274; CHCR; E430034C16Rik; MBLX; MBLX39; MBXL
Description (Vector)
Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction.
Gene ID
171170
Gene Name (Vector)
muscleblind-like 3 (Drosophila)
Gene Symbol
Mbnl3
ORF Size (aa)
1029
ORF Size (bp)
1029 bp
RefSeq ID
NM_134163
RefSeq Synonyms
NM_134163, NM_001310515, BC057157,
Species
mouse
UniGene ID
Mm.295324

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.