mouse MAVS shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Mavs.
shAAV-264299
AAV-m-MAVS-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Mavs (mitochondrial antiviral signaling protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
cardif; D430028G21Rik; IPS-1; Visa
Description (Vector)
Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.
Gene ID
228607
Gene Name (Vector)
mitochondrial antiviral signaling protein
Gene Symbol
Mavs
ORF Size (aa)
1512
ORF Size (bp)
1512 bp
RefSeq ID
NM_144888
RefSeq Synonyms
NM_144888, NM_001206385, NM_001206383, NM_001206382, BC037391, BC031352, BC025825, BC020006,
Species
mouse
UniGene ID
Mm.287226
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.