mouse MAP3K7 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Map3k7.
shAAV-264193
AAV-m-MAP3K7-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Map3k7 (mitogen-activated protein kinase kinase kinase 7). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
B430101B05; C87327; Tak1
Description (Vector)
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B.
Gene ID
26409
Gene Name (Vector)
mitogen-activated protein kinase kinase kinase 7
Gene Symbol
Map3k7
ORF Size (aa)
1821
ORF Size (bp)
1821 bp
RefSeq ID
NM_172688
RefSeq Synonyms
NM_172688, NM_009316, BC006665,
Species
mouse
UniGene ID
Mm.258589
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.