mouse MACROD1 shRNA silencing AAV

Name
AAV-m-MACROD1-shRNA

Cat No
shAAV-264067

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Mouse Macrod1.

shAAV-264067

AAV-m-MACROD1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Macrod1 (MACRO domain containing 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AI604841; AW743046; D930010J01Rik; Lrp16

Description (Vector)

Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity.

Gene ID

107227

Gene Name (Vector)

MACRO domain containing 1

Gene Symbol

Macrod1

ORF Size (aa)

732

ORF Size (bp)

732 bp

RefSeq ID

NM_134147

RefSeq Synonyms

NM_134147, BC008653,

Species

mouse

UniGene ID

Mm.439977

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.