mouse LRPPRC shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Lrpprc.
shAAV-263820
AAV-m-LRPPRC-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Lrpprc (leucine-rich PPR-motif containing). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
3110001K13Rik; C76645; Gp130; Lrp130; Lsfc
Description (Vector)
LRPPRC may play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity).
Gene ID
72416
Gene Name (Vector)
leucine-rich PPR-motif containing
Gene Symbol
Lrpprc
ORF Size (aa)
3921
ORF Size (bp)
3921 bp
RefSeq ID
NM_028233
RefSeq Synonyms
NM_028233, BC059862,
Species
mouse
UniGene ID
Mm.217027
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.