mouse KLHL20 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Klhl20.
shAAV-262906
AAV-m-KLHL20-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Klhl20 (kelch-like 20). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AI504637; D930050H05Rik; Kleip; mKIAA4210
Description (Vector)
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis. Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases.
Gene ID
226541
Gene Name (Vector)
kelch-like 20
Gene Symbol
Klhl20
ORF Size (aa)
1815
ORF Size (bp)
1815 bp
RefSeq ID
NM_001039482
RefSeq Synonyms
NM_001039482, BC019571,
Species
mouse
UniGene ID
Mm.255165
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.