mouse HIPK3 shRNA silencing AAV

Cat. No: shAAV-261309

Availability: 4-5 weeks

Name: AAV-m-HIPK3-shRNA

This is an AAV expressing shRNA for silencing of Mouse Hipk3.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Hipk3
Gene Name: homeodomain interacting protein kinase 3
Gene ID: 15259
Gene Synonyms: DYRK6; FIST3; mir-1902; PKY
ORF Size: 3576 bp
RefSeq#: NM_010434
Gene Description: Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).
UniGene ID: Mm.389331