mouse HIPK3 shRNA silencing AAV

Name
AAV-m-HIPK3-shRNA

Cat No
shAAV-261309

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Mouse Hipk3.

shAAV-261309

AAV-m-HIPK3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Hipk3 (homeodomain interacting protein kinase 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

DYRK6; FIST3; mir-1902; PKY

Description (Vector)

Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).

Gene ID

15259

Gene Name (Vector)

homeodomain interacting protein kinase 3

Gene Symbol

Hipk3

ORF Size (aa)

3576

ORF Size (bp)

3576 bp

RefSeq ID

NM_010434

RefSeq Synonyms

NM_010434, NM_001145824, BC131664,

Species

mouse

UniGene ID

Mm.389331

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.