mouse HAND2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Hand2.
shAAV-261098
AAV-m-HAND2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Hand2 (heart and neural crest derivatives expressed transcript 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AI225906; AI661148; bHLHa26; dHAND; Ehand2; Hed; Th2; Thing2
Description (Vector)
Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity).
Gene ID
15111
Gene Name (Vector)
heart and neural crest derivatives expressed transcript 2
Gene Symbol
Hand2
ORF Size (aa)
654
ORF Size (bp)
654 bp
RefSeq ID
NM_010402
RefSeq Synonyms
NM_010402, BC172639,
Species
mouse
UniGene ID
Mm.430844
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.