mouse H2AFZ shRNA silencing AAV

Name
AAV-m-H2AFZ-shRNA

Cat No
shAAV-261064

Availability
Immediate

This is an AAV expressing shRNA for silencing of Mouse H2afz.

shAAV-261064

AAV-m-H2AFZ-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse H2afz (H2A histone family, member Z). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

H2A.Z; H2a.z-1

Description (Vector)

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.

Gene ID

51788

Gene Name (Vector)

H2A histone family, member Z

Gene Symbol

H2afz

ORF Size (aa)

387

RefSeq ID

NM_016750

RefSeq Synonyms

NM_016750, NM_001316995, BC171999, BC158035, BC147478, BC079903,

Species

mouse

UniGene ID

Mm.465508

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.