mouse GRINL1A shRNA silencing AAV

Name 
AAV-m-GRINL1A-shRNA
Cat No 
shAAV-260774
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse Polr2m.

shAAV-260774
AAV-m-GRINL1A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Polr2m (polymerase (RNA) II (DNA directed) polypeptide M). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AA407243; AA408799; AI303746; AW553238; D9Wsu138e; Grinl1a; mKIAA4185
Description (Vector)
Isoform 1 appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. Isoform 1 may play a role in the Mediator complex-dependent regulation of transcription activation. Isoform 1 acts in vitro as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II.
Gene ID
28015
Gene Name (Vector)
polymerase (RNA) II (DNA directed) polypeptide M
Gene Symbol
Polr2m
ORF Size (aa)
1101
ORF Size (bp)
1101 bp
RefSeq ID
NM_178602
RefSeq Synonyms
NM_178602, NM_001164793, BC062199, BC018502,
Species
mouse
UniGene ID
Mm.21094

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.