mouse GRIN2B shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Grin2b.
shAAV-260769
AAV-m-GRIN2B-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Grin2b (glutamate receptor, ionotropic, NMDA2B (epsilon 2)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AW490526; GluN2B; Nmdar2b; NR2B
Description (Vector)
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).
Gene ID
14812
Gene Name (Vector)
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
Gene Symbol
Grin2b
ORF Size (aa)
4446
ORF Size (bp)
4446 bp
RefSeq ID
NM_008171
RefSeq Synonyms
NM_008171, BC172745,
Species
mouse
UniGene ID
Mm.436649
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.