mouse GOSR1 shRNA silencing AAV

Name
AAV-m-GOSR1-shRNA

Cat No
shAAV-260466

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Mouse Gosr1.

shAAV-260466

AAV-m-GOSR1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Gosr1 (golgi SNAP receptor complex member 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AI414660; AI426320; BB145494; GOS-28; GOSRI; GS28

Description (Vector)

Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.

Gene ID

53334

Gene Name (Vector)

golgi SNAP receptor complex member 1

Gene Symbol

Gosr1

ORF Size (aa)

753

ORF Size (bp)

753 bp

RefSeq ID

NM_016810

RefSeq Synonyms

NM_016810, BC051661, BC008542,

Species

mouse

UniGene ID

Mm.20931

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.