mouse FOXL2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Foxl2.
shAAV-259581
AAV-m-FOXL2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Foxl2 (forkhead box L2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AU045128; BPES; Pfrk; PINTO
Description (Vector)
Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.
Gene ID
26927
Gene Name (Vector)
forkhead box L2
Gene Symbol
Foxl2
ORF Size (aa)
1128
RefSeq ID
NM_012020
RefSeq Synonyms
NM_012020, BC137812, BC137811,
Species
mouse
UniGene ID
Mm.151239
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.