mouse ERCC6 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Ercc6.
shAAV-258637
AAV-m-ERCC6-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Ercc6 (excision repair cross-complementing rodent repair deficiency, complementation group 6). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
4732403I04; C130058G22Rik; CSB
Description (Vector)
Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the at sites of RNA polymerase II-blocking lesions.
Gene ID
319955
Gene Name (Vector)
excision repair cross-complementing rodent repair deficiency, complementation group 6
Gene Symbol
Ercc6
ORF Size (aa)
4446
ORF Size (bp)
4446 bp
RefSeq ID
NM_001081221
RefSeq Synonyms
NM_001081221, BC167234,
Species
mouse
UniGene ID
Mm.318310
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.