mouse WAC shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Wac.
shAAV-258422
AAV-m-WAC-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Wac (WW domain containing adaptor with coiled-coil). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
1110067P07Rik; A230035H12Rik; AI256735; AI256776; Wwp4
Description (Vector)
Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. May negatively regulate the ubiquitin proteasome pathway.
Gene ID
225131
Gene Name (Vector)
WW domain containing adaptor with coiled-coil
Gene Symbol
Wac
ORF Size (aa)
1941
ORF Size (bp)
1941 bp
RefSeq ID
NM_153085
RefSeq Synonyms
NM_153085, NM_001282093, NM_001146298, BC080851,
Species
mouse
UniGene ID
Mm.476731
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.