mouse EFNB3 shRNA silencing AAV

Name
AAV-m-EFNB3-shRNA

Cat No
shAAV-257821

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Efnb3.

shAAV-257821

AAV-m-EFNB3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Efnb3 (ephrin B3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

EFL-6; ELF-3; Elk-L3; Epl8; LERK-8; NLERK-2

Description (Vector)

Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity).

Gene ID

13643

Gene Name (Vector)

ephrin B3

Gene Symbol

Efnb3

ORF Size (aa)

1023

ORF Size (bp)

1023 bp

RefSeq ID

NM_007911

RefSeq Synonyms

NM_007911, BC058617, BC052001,

Species

mouse

UniGene ID

Mm.249637

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.