mouse DMAP1 shRNA silencing AAV

Name
AAV-m-DMAP1-shRNA

Cat No
shAAV-257246

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Mouse Dmap1.

shAAV-257246

AAV-m-DMAP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Dmap1 (DNA methyltransferase 1-associated protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

1500016M21Rik; Dmtap1; DNMAP1; DNMTAP1; mKIAA1425

Description (Vector)

Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity.

Gene ID

66233

Gene Name (Vector)

DNA methyltransferase 1-associated protein 1

Gene Symbol

Dmap1

ORF Size (aa)

1407

ORF Size (bp)

1407 bp

RefSeq ID

NM_023178

RefSeq Synonyms

NM_023178, BC045160,

Species

mouse

UniGene ID

Mm.29142

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.