mouse DKK3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Dkk3.
shAAV-257208
AAV-m-DKK3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Dkk3 (dickkopf WNT signaling pathway inhibitor 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AW061014; C87148
Description (Vector)
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
Gene ID
50781
Gene Name (Vector)
dickkopf WNT signaling pathway inhibitor 3
Gene Symbol
Dkk3
ORF Size (aa)
1050
ORF Size (bp)
1050 bp
RefSeq ID
NM_015814
RefSeq Synonyms
NM_015814, BC050934, BC046304,
Species
mouse
UniGene ID
Mm.55143
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.