mouse DERL1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Derl1.
shAAV-257097
AAV-m-DERL1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Derl1 (Der1-like domain family, member 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
1110021N07Rik; AI195141; AW551338; Derlin-1
Description (Vector)
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.
Gene ID
67819
Gene Name (Vector)
Der1-like domain family, member 1
Gene Symbol
Derl1
ORF Size (aa)
756
ORF Size (bp)
756 bp
RefSeq ID
NM_024207
RefSeq Synonyms
NM_024207, BC085490, BC003454,
Species
mouse
UniGene ID
Mm.444431
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.