mouse DDR1 shRNA silencing AAV

Name
AAV-m-DDR1-shRNA

Cat No
shAAV-256910

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Mouse Ddr1.

shAAV-256910

AAV-m-DDR1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Ddr1 (discoidin domain receptor family, member 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

6030432F18; AI323681; Cak; CD167a; Nep; PTK3A

Description (Vector)

Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.

Gene ID

12305

Gene Name (Vector)

discoidin domain receptor family, member 1

Gene Symbol

Ddr1

ORF Size (aa)

2061

ORF Size (bp)

2061 bp

RefSeq ID

NM_007584

RefSeq Synonyms

NM_172962, NM_007584, NM_001198833, NM_001198831, BC065998,

Species

mouse

UniGene ID

Mm.5021

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.