mouse DAPK2 shRNA silencing AAV

Name
AAV-m-DAPK2-shRNA

Cat No
shAAV-256805

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Mouse Dapk2.

shAAV-256805

AAV-m-DAPK2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Dapk2 (death-associated protein kinase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Description (Vector)

Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation|Function: Isoform 2 can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death.

Gene ID

13143

Gene Name (Vector)

death-associated protein kinase 2

Gene Symbol

Dapk2

ORF Size (aa)

1113

ORF Size (bp)

1113 bp

RefSeq ID

NM_010019

RefSeq Synonyms

NM_010019, BC022165,

Species

mouse

UniGene ID

Mm.335252

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.