mouse CSK shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Csk.
shAAV-256225
AAV-m-CSK-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Csk (c-src tyrosine kinase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AW212630; p50CSK
Description (Vector)
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
Gene ID
12988
Gene Name (Vector)
c-src tyrosine kinase
Gene Symbol
Csk
ORF Size (aa)
1353
ORF Size (bp)
1353 bp
RefSeq ID
NM_007783
RefSeq Synonyms
NM_007783, NM_001304761, BC052006, BC018394,
Species
mouse
UniGene ID
Mm.470150
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.