mouse COL4A1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Col4a1.
shAAV-255856
AAV-m-COL4A1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Col4a1 (collagen, type IV, alpha 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Bru; Col4a-1; Raw; Svc
Description (Vector)
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen|Function: Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin.
Gene ID
12826
Gene Name (Vector)
collagen, type IV, alpha 1
Gene Symbol
Col4a1
ORF Size (aa)
4689
ORF Size (bp)
4689 bp
RefSeq ID
NM_009931
RefSeq Synonyms
NM_009931, BC072650,
Species
mouse
UniGene ID
Mm.738
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.