mouse CLOCK shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Clock.
shAAV-255683
AAV-m-CLOCK-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Clock (circadian locomotor output cycles kaput). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
5330400M04Rik; KAT13D
Description (Vector)
ARNTL/2-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. Activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. Has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression (By similarity). Acetylates primarily histones H3 and H4 (By similarity). Acetylates also a non-histone substrate: ARNTL (By similarity). Plays a role in DNA damage response (DDR) signaling during the S phase.
Gene ID
12753
Gene Name (Vector)
circadian locomotor output cycles kaput
Gene Symbol
Clock
ORF Size (aa)
2568
ORF Size (bp)
2568 bp
RefSeq ID
NM_007715
RefSeq Synonyms
NM_007715, NM_001305222, NM_001289826, BC156741, BC148468,
Species
mouse
UniGene ID
Mm.392894
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.