mouse CIITA shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Ciita.
shAAV-255507
AAV-m-CIITA-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Ciita (class II transactivator). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C2ta; EG669998; Gm9475; Mhc2ta
Description (Vector)
Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter.
Gene ID
12265
Gene Name (Vector)
class II transactivator
Gene Symbol
Ciita
ORF Size (aa)
3237
ORF Size (bp)
3237 bp
RefSeq ID
NM_007575
RefSeq Synonyms
NM_007575, NM_001302619, NM_001302618, NM_001243761, NM_001243760, BC148699, BC140358,
Species
mouse
UniGene ID
Mm.249560
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.