mouse CDK6 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Cdk6.
shAAV-255173
AAV-m-CDK6-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Cdk6 (cyclin-dependent kinase 6). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AI504062; Crk2
Description (Vector)
Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans.
Gene ID
12571
Gene Name (Vector)
cyclin-dependent kinase 6
Gene Symbol
Cdk6
ORF Size (aa)
981
RefSeq ID
NM_009873
RefSeq Synonyms
NM_009873, BC120595, BC119360,
Species
mouse
UniGene ID
Mm.399714
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.