mouse CDH5 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Cdh5.
shAAV-255151
AAV-m-CDH5-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Cdh5 (cadherin 5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
7B4; 7B4/cadherin-5; AA408225; cadherin-5; CD antigen CD144; Cd144; vascular endothelial cadherin; Vec; VEcad; VE-Cad; VE-cadherin; VECD
Description (eCommerce)
Cadherins are calcium-dependent cell adhesion proteins that preferentially interact with themselves in a homophilic manner in adjacent cells. VE-Cadherin, or Cadherin-5 plays an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton and acts in concert with KRIT1 and MPP5 to establish and maintain correct endothelial cell polarity and vascular lumen. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P33151].
Description (Vector)
Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.
Gene ID
12562
Gene Name (eCommerce)
cadherin 5
Gene Name (Vector)
cadherin 5
Gene Symbol
Cdh5
NCBI Taxonomy ID (eCommerce)
10090.0
ORF Size (aa)
2355
ORF Size (bp)
2355 bp
Protein Name (eCommerce)
Cadherin-5
RefSeq ID
NM_009868
RefSeq Synonyms
NM_009868, BC054790,
Research Areas
Apoptosis,Bladder Cancer,Breast Cancer,Cancer,Cell Cycle,Cytoskeleton,EGFR Signaling,FGF Signaling,Golgi Apparatus,HGF Signaling,Hippo Signaling,Immunology,Neurobiology,Neurodevelopment,RAC1 Signaling,Signal Transduction,TGF-beta Signaling,Translational Control,Wnt Signaling
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,immunology,neurobiology,signal_transduction,transcription_translation
Species
mouse
Target Sentence
Cadherins are calcium-dependent cell adhesion proteins that preferentially interact with themselves in a homophilic manner in adjacent cells. VE-Cadherin, or Cadherin-5 plays an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton and acts in concert with KRIT1 and MPP5 to establish and maintain correct endothelial cell polarity and vascular lumen. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P33151].
UniGene ID
Mm.21767
UniProt ID (eCommerce)
P55284
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.