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mouse CD79A shRNA silencing AAV

Name 
AAV-m-CD79A-shRNA
Cat No 
shAAV-255045
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse Cd79a.

shAAV-255045
AAV-m-CD79A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Cd79a (CD79A antigen (immunoglobulin-associated alpha)). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
B-cell antigen receptor complex-associated protein alpha chain; CD antigen CD79a; Iga; Igalpha; Ig-alpha; Ly54; Ly-54; mb-1; MB-1 membrane glycoprotein; membrane-bound immunoglobulin-associated protein; surface IgM-associated protein
Description (eCommerce)
CD79A is required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. CD79A is also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P11912].
Description (Vector)
Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.
Gene ID
12518
Gene Name (eCommerce)
CD79A antigen (immunoglobulin-associated alpha)
Gene Name (Vector)
CD79A antigen (immunoglobulin-associated alpha)
Gene Symbol
Cd79a
NCBI Taxonomy ID (eCommerce)
10090.0
ORF Size (aa)
663
Protein Name (eCommerce)
B-cell antigen receptor complex-associated protein alpha chain
RefSeq ID
NM_007655
RefSeq Synonyms
NM_007655, BC027633,
Research Areas
B-cell Receptor Signaling,Immunology,Signal Transduction
Research Areas (Faceted)
signal_transduction,immunology
Species
mouse
Target Sentence
CD79A is required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. CD79A is also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P11912].
UniGene ID
Mm.1355
UniProt ID (eCommerce)
P11911

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.