mouse CBX7 shRNA silencing AAV

Name
AAV-m-CBX7-shRNA

Cat No
shAAV-254638

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Cbx7.

shAAV-254638

AAV-m-CBX7-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Cbx7 (chromobox 7). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

1600014J01Rik; AI851678; D15Ertd417e

Description (Vector)

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.

Gene ID

52609

Gene Name (Vector)

chromobox 7

Gene Symbol

Cbx7

ORF Size (aa)

477

ORF Size (bp)

477 bp

RefSeq ID

NM_144811

RefSeq Synonyms

NM_144811, BC021398,

Species

mouse

UniGene ID

Mm.323442

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.