mouse CACNA1S shRNA silencing AAV

Name
AAV-m-CACNA1S-shRNA

Cat No
shAAV-254368

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Cacna1s.

shAAV-254368

AAV-m-CACNA1S-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Cacna1s (calcium channel, voltage-dependent, L type, alpha 1S subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AW493108; Cav1.1; Cchl1a3; fmd; mdg; sj

Description (Vector)

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle.

Gene ID

12292

Gene Name (Vector)

calcium channel, voltage-dependent, L type, alpha 1S subunit

Gene Symbol

Cacna1s

ORF Size (aa)

5559

ORF Size (bp)

5559 bp

RefSeq ID

NM_001081023

RefSeq Synonyms

NM_014193, NM_001081023, BC172641,

Species

mouse

UniGene ID

Mm.4418

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.