mouse BRAP shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Brap.
shAAV-254068
AAV-m-BRAP-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Brap (BRCA1 associated protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
3010002G07Rik; BRAP2; IMP
Description (Vector)
Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.
Gene ID
72399
Gene Name (Vector)
BRCA1 associated protein
Gene Symbol
Brap
ORF Size (aa)
1125
ORF Size (bp)
1125 bp
RefSeq ID
NM_028227
RefSeq Synonyms
NM_028227, NM_001289544, NM_001289543, BC038490,
Species
mouse
UniGene ID
Mm.153372
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.