mouse APBB1 shRNA silencing AAV

Name
AAV-m-APBB1-shRNA

Cat No
shAAV-252801

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Mouse Apbb1.

shAAV-252801

AAV-m-APBB1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Apbb1 (amyloid beta (A4) precursor protein-binding, family B, member 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Fe65; Rir

Description (Vector)

Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its trancription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).

Gene ID

11785

Gene Name (Vector)

amyloid beta (A4) precursor protein-binding, family B, member 1

Gene Symbol

Apbb1

ORF Size (aa)

1155

RefSeq ID

NM_009685

RefSeq Synonyms

NM_009685, NM_001310600, NM_001253887, NM_001253886, NM_001253885, BC048395,

Species

mouse

UniGene ID

Mm.38469

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.