mouse ANPEP shRNA silencing AAV

Name
AAV-m-ANPEP-shRNA

Cat No
shAAV-252731

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Anpep.

shAAV-252731

AAV-m-ANPEP-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Anpep (alanyl (membrane) aminopeptidase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AP-M; AP-N; Apn; Cd13; P150

Description (Vector)

Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types including small intestinal and tubular epithelial cells, macrophages, granulocytes and synaptic membranes from the CNS. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection.

Gene ID

16790

Gene Name (Vector)

alanyl (membrane) aminopeptidase

Gene Symbol

Anpep

ORF Size (aa)

2901

ORF Size (bp)

2901 bp

RefSeq ID

NM_008486

RefSeq Synonyms

NM_008486, BC040792, BC017011, BC005431,

Species

mouse

UniGene ID

Mm.4487

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.