mouse AMOTL2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Amotl2.
shAAV-252582
AAV-m-AMOTL2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Amotl2 (angiomotin-like 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AW549739; C79691; Lccp; MASCOT; mKIAA0989
Description (Vector)
Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.
Gene ID
56332
Gene Name (Vector)
angiomotin-like 2
Gene Symbol
Amotl2
ORF Size (aa)
2319
ORF Size (bp)
2319 bp
RefSeq ID
NM_019764
RefSeq Synonyms
NM_019764, BC027824,
Species
mouse
UniGene ID
Mm.21145
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.