mouse AGRP shRNA silencing AAV

Name
AAV-m-AGRP-shRNA

Cat No
shAAV-252247

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Agrp.

shAAV-252247

AAV-m-AGRP-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Agrp (agouti related neuropeptide). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Agrt; Art

Description (Vector)

Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.

Gene ID

11604

Gene Name (Vector)

agouti related neuropeptide

Gene Symbol

Agrp

ORF Size (aa)

396

RefSeq ID

NM_007427

RefSeq Synonyms

NM_007427, NM_001271806, BC079902,

Species

mouse

UniGene ID

Mm.441696

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.