mouse AGER shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Ager.
shAAV-252223
AAV-m-AGER-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Ager (advanced glycosylation end product-specific receptor). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
RAGE
Description (Vector)
Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space.
Gene ID
11596
Gene Name (Vector)
advanced glycosylation end product-specific receptor
Gene Symbol
Ager
ORF Size (aa)
1209
ORF Size (bp)
1209 bp
RefSeq ID
NM_007425
RefSeq Synonyms
NM_007425, NM_001271424, NM_001271423, NM_001271422, BC061182,
Species
mouse
UniGene ID
Mm.3383
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.