mouse ARHGAP24 shRNA silencing AAV

Name
AAV-m-ARHGAP24-shRNA

Cat No
shAAV-250910

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Mouse Arhgap24.

shAAV-250910

AAV-m-ARHGAP24-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Arhgap24 (Rho GTPase activating protein 24). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

0610025G21Rik

Description (Vector)

Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.

Gene ID

231532

Gene Name (Vector)

Rho GTPase activating protein 24

Gene Symbol

Arhgap24

ORF Size (aa)

1965

ORF Size (bp)

1965 bp

RefSeq ID

NM_146161

RefSeq Synonyms

NM_146161, NM_029270, NM_001346585, NM_001286468, BC027070, BC025502, BC023344,

Species

mouse

UniGene ID

Mm.440191

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.