mouse 2400001E08RIK shRNA silencing AAV

Name 
AAV-m-2400001E08RIK-shRNA
Cat No 
shAAV-250719
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse Lamtor1.

shAAV-250719
AAV-m-2400001E08RIK-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Lamtor1 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
2400001E08Rik; p18; Pdro
Description (Vector)
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, recruits the Rag GTPases and the mTORC1 complex to lysosomes, a key step in activation of the TOR signaling cascade by amino acids. Directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.
Gene ID
66508
Gene Name (Vector)
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
Gene Symbol
Lamtor1
ORF Size (aa)
486
RefSeq ID
NM_025605
RefSeq Synonyms
NM_025605, BC126973, BC096412, BC092062, BC020142,
Species
mouse
UniGene ID
Mm.359278

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.