mouse 2010110P09RIK shRNA silencing AAV

Name
AAV-m-2010110P09RIK-shRNA

Cat No
shAAV-250556

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Chp2.

shAAV-250556

AAV-m-2010110P09RIK-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Chp2 (calcineurin-like EF hand protein 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

2010110P09Rik; Cbhp2

Description (Vector)

Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.

Gene ID

70261

Gene Name (Vector)

calcineurin-like EF hand protein 2

Gene Symbol

Chp2

ORF Size (aa)

591

RefSeq ID

NM_027363

RefSeq Synonyms

NM_027363, BC119204, BC119202,

Species

mouse

UniGene ID

Mm.96997

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.