human EP400 shRNA silencing AAV

Name 
AAV-h-EP400-shRNA
Cat No 
shAAV-234223
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human EP400.

shAAV-234223
AAV-h-EP400-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human EP400 (E1A binding protein p400). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CAG repeat protein 32; CAGH32; domino homolog; E1A-binding protein p400; hDomino; hDomino(p400); P400; p400 kDa SWI2/SNF2-related protein; p400 SWI2/SNF2-related protein; TNRC12; trinucleotide repeat containing 12; trinucleotide repeat-containing gene 12 protein
Description (eCommerce)
p400 belongs to the SWI2/SNF2 family of chromatin remodeling proteins and is a component of the NuA4 histone acetyltransferase complex. In this complex p400 positively regulates transcription by modifying nucleosome structure. P400 has also been found to play a role in the p52-p21 pathway that regulates p21 transcription and senescence as well as the ARF-p53 pathway that couples cell proliferation to apoptosis.
Gene ID
57634
Gene Name (eCommerce)
E1A binding protein p400
Gene Name (Vector)
E1A binding protein p400
Gene Symbol
EP400
HGNC ID
HGNC:11958
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2958
ORF Size (bp)
2958 bp
Protein Name (eCommerce)
E1A-binding protein p400
RefSeq ID
NM_015409
RefSeq Synonyms
NM_015409, BC037208,
Research Areas
Chromatin Remodeling,Helicase Activity,Histone Modification
Research Areas (Faceted)
cell_biology,genetics
Species
human
Target Sentence
p400 belongs to the SWI2/SNF2 family of chromatin remodeling proteins and is a component of the NuA4 histone acetyltransferase complex. In this complex p400 positively regulates transcription by modifying nucleosome structure. P400 has also been found to play a role in the p52-p21 pathway that regulates p21 transcription and senescence as well as the ARF-p53 pathway that couples cell proliferation to apoptosis.
UniProt ID (eCommerce)
Q96L91

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.