human TLK2 shRNA silencing AAV

Name 
AAV-h-TLK2-shRNA
Cat No 
shAAV-233967
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human TLK2.

shAAV-233967
AAV-h-TLK2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TLK2 (tousled like kinase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
HsHPK; MRD57; PKU-ALPHA; serine/threonine-protein kinase tousled-like 2; Tousled-like kinase 2
Description (eCommerce)
Tousled-like kinase 2 (TLK2) is a serine/threonine kinase involved in chromatin assembly and the DNA damage response. The tousled (Tsl) kinase was first identified in Arabidopsis thaliana and speculated to be involved in cell division during patterning of plant organs. There are two tousled-like kinases in humans, TLK1 and TLK2, that can dimerize or heterodimerize for function and can be phosphorylated and inactivated by Chk1 in response to DNA damage. The chromatin assembly factor, Asf1 (anti-silencing function 1), has been reported as a substrate for both TLK1 and TLK2.
Description (Vector)
The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.(supplied by OMIM, Apr 2004)
Gene ID
11011
Gene Name (eCommerce)
tousled like kinase 2
Gene Name (Vector)
tousled like kinase 2
Gene Symbol
TLK2
HGNC ID
HGNC:11842
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2494
ORF Size (bp)
2494 bp
Protein Name (eCommerce)
Serine/threonine-protein kinase tousled-like 2
RefSeq ID
NM_006852
RefSeq Synonyms
NM_006852, NM_001330418, NM_001284363, NM_001284333, NM_001112707, BC044925,
Research Areas
Autophagy,Cell Cycle,Chromatin Remodeling,Cytoskeleton,DNA Damage/Repair,Kinase/Phosphatase,Signal Transduction
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,signal_transduction,transcription_translation
Species
human
Target Sentence
Tousled-like kinase 2 (TLK2) is a serine/threonine kinase involved in chromatin assembly and the DNA damage response. The tousled (Tsl) kinase was first identified in Arabidopsis thaliana and speculated to be involved in cell division during patterning of plant organs. There are two tousled-like kinases in humans, TLK1 and TLK2, that can dimerize or heterodimerize for function and can be phosphorylated and inactivated by Chk1 in response to DNA damage. The chromatin assembly factor, Asf1 (anti-silencing function 1), has been reported as a substrate for both TLK1 and TLK2.
UniProt ID (eCommerce)
Q86UE8

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.