human PCDHA7 shRNA silencing AAV

Name
AAV-h-PCDHA7-shRNA

Cat No
shAAV-232332

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human PCDHA7.

shAAV-232332

AAV-h-PCDHA7-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PCDHA7 (protocadherin alpha 7). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CNR4; CNRN4; CNRS4; CRNR4; PCDH-ALPHA7

Description (Vector)

PCDHA7 is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.

Gene ID

56141

Gene Name (Vector)

protocadherin alpha 7

Gene Symbol

PCDHA7

HGNC ID

HGNC:8673

ORF Size (aa)

2811

ORF Size (bp)

2811 bp

RefSeq ID

NM_018910

RefSeq Synonyms

NM_031852, NM_018910, BC156893, BC156820, BC148656,

Species

human

UniGene ID

Hs.

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.