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human TMEM189-UBE2V1 shRNA silencing AAV

Name 
AAV-h-TMEM189-UBE2V1-shRNA
Cat No 
shAAV-232191
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human TMEM189-UBE2V1.

shAAV-232191
AAV-h-TMEM189-UBE2V1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TMEM189-UBE2V1 (TMEM189-UBE2V1 readthrough). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CROC-1B; CROC1B; KUA-UEV
Description (Vector)
The TMEM189-UEV mRNA is an infrequent but naturally occurring read-through transcript of the neighboring TMEM189 and UBE2V1 genes. Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein produced by this transcript has UEV1 B domains but the protein is localized to the cytoplasm rather than to the nucleus. The significance of this read-through mRNA and the function of its protein product has not yet been determined.
Gene ID
387522
Gene Name (Vector)
TMEM189-UBE2V1 readthrough
Gene Symbol
TMEM189-UBE2V1
HGNC ID
HGNC:33521
ORF Size (aa)
1113
RefSeq ID
NM_199203
RefSeq Synonyms
NM_199203, BC172339,
Species
human
UniGene ID
Hs.

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.