human GFRA1 shRNA silencing AAV

Name 
AAV-h-GFRA1-shRNA
Cat No 
shAAV-231958
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human GFRA1.

shAAV-231958
AAV-h-GFRA1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GFRA1 (GDNF family receptor alpha 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
GDNFR; GDNFRA; GFR-ALPHA-1; RET1L; RETL1; TRNR1
Description (Vector)
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene.
Gene ID
2674
Gene Name (Vector)
GDNF family receptor alpha 1
Gene Symbol
GFRA1
HGNC ID
HGNC:4243
ORF Size (aa)
1383
ORF Size (bp)
1383 bp
RefSeq ID
NM_005264
RefSeq Synonyms
NM_145793, NM_005264, NM_001145453, BC014962,
Species
human
UniGene ID
Hs.388347

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.