human CLDN10 shRNA silencing AAV

Name
AAV-h-CLDN10-shRNA

Cat No
shAAV-231872

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CLDN10.

shAAV-231872

AAV-h-CLDN10-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CLDN10 (claudin 10). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CPETRL3; OSP-L

Description (Vector)

CLDN10 encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The expression level of this gene is associated with recurrence of primary hepatocellular carcinoma. Six alternatively spliced transcript variants encoding different isoforms have been reported, but the transcript sequences of some variants are not determined.

Gene ID

9071

Gene Name (Vector)

claudin 10

Gene Symbol

CLDN10

ORF Size (aa)

687

ORF Size (bp)

687 bp

RefSeq ID

NM_006984

RefSeq Synonyms

NM_182848, NM_006984, NM_001160100, BC010920,

Species

human

UniGene ID

Hs.534377

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.