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human TNIP1 shRNA silencing AAV

Name 
AAV-h-TNIP1-shRNA
Cat No 
shAAV-231764
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human TNIP1.

shAAV-231764
AAV-h-TNIP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TNIP1 (TNFAIP3 interacting protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
75
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
A20-binding inhibitor of NF-kappa-B activation 1; ABIN-1; HIV-1 Nef-interacting protein; hVAN; NAF1; Nef-associated factor 1; Nef-associated factor 1 SNP; nip40-1; TNFAIP3-interacting protein 1; VAN; virion-associated nuclear shuttling protein
Description (eCommerce)
TNFAIP3-interacting protein 1 (TNIP1) is an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the regulation of nuclear factor kappa-B activation. Mutations in the TNIP1 gene have been associated with psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus [taken from NCBI Entrez Gene (Gene ID: 10318)].
Description (Vector)
TNIP1 encodes an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the regulation of nuclear factor kappa-B activation. Mutations in this gene have been associated with psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
10318
Gene Name (eCommerce)
TNFAIP3 interacting protein 1
Gene Name (Vector)
TNFAIP3 interacting protein 1
Gene Symbol
TNIP1
HGNC ID
HGNC:16903
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1911
ORF Size (bp)
1911 bp
Protein Name (eCommerce)
TNFAIP3-interacting protein 1
RefSeq ID
NM_006058
RefSeq Synonyms
NM_006058, NM_001258456, NM_001258455, NM_001258454, NM_001252393, NM_001252392, NM_001252391, NM_001252390, NM_001252386, NM_001252385, BC014008, BC012133, BC007666,
Research Areas
EGFR Signaling,Host-Virus Interactions,Immunology,NF-kB Signaling,Signal Transduction,Toll-like Receptor Signaling,Translational Control
Research Areas (Faceted)
cell_biology,immunology,infectious_disease,signal_transduction,transcription_translation
Species
human
Target Sentence
TNFAIP3-interacting protein 1 (TNIP1) is an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the regulation of nuclear factor kappa-B activation. Mutations in the TNIP1 gene have been associated with psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus [taken from NCBI Entrez Gene (Gene ID: 10318)].
UniGene ID
Hs.355141
UniProt ID (eCommerce)
Q15025

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.