human XRCC3 shRNA silencing AAV

Name
AAV-h-XRCC3-shRNA

Cat No
shAAV-231453

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human XRCC3.

shAAV-231453

AAV-h-XRCC3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human XRCC3 (X-ray repair cross complementing 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CMM6

Description (Vector)

XRCC3 encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. XRCC3 functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified.

Gene ID

7517

Gene Name (Vector)

X-ray repair cross complementing 3

Gene Symbol

XRCC3

HGNC ID

HGNC:12830

ORF Size (aa)

1041

RefSeq ID

NM_005432

RefSeq Synonyms

NM_005432, NM_001100119, NM_001100118, BC011725, BC001036,

Species

human

UniGene ID

Hs.719391

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.