human GORASP1 shRNA silencing AAV

Name 
AAV-h-GORASP1-shRNA
Cat No 
shAAV-231324
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human GORASP1.

shAAV-231324
AAV-h-GORASP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GORASP1 (golgi reassembly stacking protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Golgi peripheral membrane protein p65; Golgi phosphoprotein 5; Golgi reassembly and stacking protein 1; golgi reassembly stacking protein 1, 65kDa; Golgi reassembly-stacking protein 1; golgi reassembly-stacking protein of 65 kDa; GOLPH5; GRASP65; P65
Description (eCommerce)
Golgi reassembly-stacking protein of 65 kDa (GRASP65) is a stacking factor involved in the postmitotic assembly of Golgi stacks from mitotic Golgi fragments. GRASP65 is a key structural protein required for the maintenance of the Golgi apparatus integrity: its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis. It also mediates, via its interaction with GM130, the docking of transport vesicles with the Golgi membranes [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BQQ3].
Description (Vector)
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a membrane protein involved in establishing the stacked structure of the Golgi apparatus. It is a caspase-3 substrate, and cleavage of this encoded protein contributes to Golgi fragmentation in apoptosis. This encoded protein can form a complex with the Golgi matrix protein GOLGA2, and this complex binds to the vesicle docking protein p115. Several alternatively spliced transcript variants of this gene have been identified, but their full-length natures have not been determined.
Gene ID
64689
Gene Name (eCommerce)
golgi reassembly stacking protein 1
Gene Name (Vector)
golgi reassembly stacking protein 1
Gene Symbol
GORASP1
HGNC ID
HGNC:16769
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1323
ORF Size (bp)
1323 bp
Protein Name (eCommerce)
Golgi reassembly-stacking protein 1
RefSeq ID
NM_031899
RefSeq Synonyms
NM_031899, NM_001278790, NM_001278789, BC103827, BC103826, BC075854,
Research Areas
Cell Cycle,Golgi Apparatus,PLK1 Signaling,Signal Transduction,Transport
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,signal_transduction
Species
human
Target Sentence
Golgi reassembly-stacking protein of 65 kDa (GRASP65) is a stacking factor involved in the postmitotic assembly of Golgi stacks from mitotic Golgi fragments. GRASP65 is a key structural protein required for the maintenance of the Golgi apparatus integrity: its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis. It also mediates, via its interaction with GM130, the docking of transport vesicles with the Golgi membranes [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BQQ3].
UniGene ID
Hs.719183
UniProt ID (eCommerce)
Q9BQQ3

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.