human RNF31 shRNA silencing AAV

Name
AAV-h-RNF31-shRNA

Cat No
shAAV-230057

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human RNF31.

shAAV-230057

AAV-h-RNF31-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RNF31 (ring finger protein 31). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

E3 ubiquitin-protein ligase RNF31; HOIL-1-interacting protein; HOIP; Paul; RING finger protein 31; RING-type E3 ubiquitin transferase RNF31; ZIBRA; zinc in-between-RING-finger ubiquitin-associated domain protein

Description (eCommerce)

RING finger protein 31 is an E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96EP0].

Description (Vector)

RNF31 contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions.

Gene ID

55072

Gene Name (eCommerce)

ring finger protein 31

Gene Name (Vector)

ring finger protein 31

Gene Symbol

RNF31

HGNC ID

HGNC:16031

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

3219

ORF Size (bp)

3219 bp

Protein Name (eCommerce)

E3 ubiquitin-protein ligase RNF31

RefSeq ID

NM_017999

RefSeq Synonyms

NM_017999, NM_001310332, BC017376, BC012077,

Research Areas

CD40 Signaling,Immunology,NF-kB Signaling,Signal Transduction,T-cell Receptor Signaling,Toll-like Receptor Signaling,Ubiquitination,Zinc-finger

Research Areas (Faceted)

cell_biology,immunology,signal_transduction

Species

human

Target Sentence

RING finger protein 31 is an E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96EP0].

UniGene ID

Hs.375217

UniProt ID (eCommerce)

Q96EP0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.